Is there downtime required when changing the VXLAN Port?

Hello,

We are now at NSX version 6.2.4 and the VXLAN Port is still at 8472 and needs to be updated to 4789.

After looking at this article I can't tell if there is downtime needed or if this is a simple change?

Change VXLAN Port

Also second question what is the best way to make this change if you have a cross vCenter NSX configuration?