A few users in the last week are unable to double-click on their second monitor when the VDI is spanned across 2 monitors. It still works fine on the primary monitor.
The only change I can think of is we recently updated of the Horizon client from 5.2.0 to 5.2.1, but I'm not 100% sure if it started immediately after that.
We're running 7.10, agent 5.2.1, nvidia GRID, and Windows 10 1903 guest VM.